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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Caffeic acid phenethyl ester, Cisplatin
Phytochemical Name Caffeic acid phenethyl ester (PubChem CID: 5281787 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 323
Ref_1
Pair Name Caffeic acid phenethyl ester, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression PSMD9 hsa5715
Up-regulation Expression TP53 hsa7157
Down-regulation Expression USP8 hsa9101
In Vitro Model TOV-112D Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_3612
IGROV-1/Pt1 Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_EQ62
In Vivo Model Exponentially growing cells (1×10⁷/mouse) were inoculated i.p. or s.c. into the right flank on day 0 forming experimental groups of 7 animals.
Result This study reveals the therapeutic potential of CAPE in cisplatin-resistant ovarian tumors as well as in tumors expressing USP8.
03. Reference
No. Title Href
1 Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells. Biochem Pharmacol. 2022 Mar;197:114900. doi: 10.1016/j.bcp.2021.114900. Click
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